منابع مشابه
Spaced just right
Trimming ERAD U biquitins are zip codes for proteins heading to the proteasome. But misfolded ER proteins must be deubiquitinated before they are degraded, as shown by Wang et al. on page 963. Misfolded ER proteins are sent back through the ER membrane into the cytosol by the p97 ATPase. Upon reaching the membrane’s cytosolic side, the substrates are modifi ed by ubiquitin ligases. Wang et al. ...
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J u s t-r i g h t s p i r a l s ynamin-related proteins regulate membrane dynamics throughout the cell. Ingerman et al. report on page 1021 that these proteins form large polymers that are structurally tailored to fit their individual jobs. The canonical protein in the family, dy-namin-1, constricts the necks of clathrin-coated pits during endocytosis. In the process, it assembles into rings th...
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By the CAP Theorem, a distributed data storage system can ensure either Consistency under Partition (CP) or Availability under Partition (AP), but not both. This has led to a split between CP databases, in which updates are synchronous, and AP databases, where they are asynchronous. However, there is no inherent reason to treat all updates identically: simply, the system should be as available ...
متن کاملChild welfare worker caseload: what's just right?
This study was designed to establish a caseload standard for child welfare workers. Understanding reasonable workload expectations for child welfare workers is a cornerstone of quality service provision and the recruitment and retention of qualified workers. Because of the analytic complexity of this question, qualitative and quantitative methods were used.The mixed methods included focus group...
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At extremely low temperatures, the fact that atoms and molecules obey either Bose or Fermi statistics starts to dominate their behavior. When the density is sufficiently high, and the temperature is below a critical value, a thermal gas of identical Bose atoms precipitates into a collective state known as a Bose-Einstein condensate (BEC). In this quantum degenerate gas, all atoms are trapped in...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1747iti2